Author Archives: B Merritt

Arts Week 2017: What goes around. Fifty years of ‘The Third Policeman’

This post was contributed by Professor Martin Paul Eve.

the-third-policemanLast night, Tuesday 16 May 2017, I attended “What Goes Around: Fifty Years of The Third Policeman” as part of Birkbeck’s Arts Week.

As its name suggests, this event, hosted by Dr Joe Brooker and Tobias Harris, centred around the half-century of the publication of Flann O’Brien’s extraordinary novel. Brooker and Harris were joined on-stage by a cast of readers who punctuated the evening with performances from the text (even if some were perhaps rightly reluctant to attempt Irish accents).

The evening was paced in such a way as to be accessible to those coming fresh to O’Brien’s work and consisted of a biography, a publication history, and then several passages of close reading and discussion. For instance, Harris began by detailing the strange writerly life of Flann O’Brien (which is, in fact, a pseudonym of Brian O’Nolan, who also wrote under several other aliases, including Myles na gCopaleen). What was particularly interesting here – and that I did not know beforehand – was that that all but 240 already-sold copies of O’Nolan’s first novel, At Swim-Two-Birds, were destroyed due to bombing during World War II. Indeed, over the course of the evening it became clear that World War II was a significant factor in O’Nolan’s difficult publishing career.

With the biographical angle covered, Harris and Brooker then moved to give a background to The Third Policeman; a novel never published in O’Nolan’s own lifetime. This is no mean feat, since the novel features extraordinary twists of logic and physics. In essence, the unnamed narrator is transported to a fantastical realm (a “parish” of sorts) where the police force are obsessed only with recovering stolen bicycles. That the narrator does not possess a bicycle is a source of great concern to them. The narrative features several other curious turns, such as a spear where the point is so sharp that it protrudes invisibly many inches in front of the point we can see. “You’re missing the point”, one of the policeman remarks, as though as much at the reader as the spear. Further, it transpires later in the text that the reason the policeman have so many stolen bicycles to investigate is that they are, themselves, stealing the bikes. They do so since they believe that the longer a person spends on the bicycle, the more he or she becomes merged as some kind of cyborg-like hybrid of (wo)man-bicycle. This is, indeed, a most strange novel.

Discussions with the audience ranged from the novel’s metafictive implications – that is: how much is this is a novel about the acts of reading and writing themselves? – through its resonances with the physical sciences up to an appraisal of its legacy. It was, though, perhaps the latter two areas that received the most attention. For while some aspects of The Third Policeman make sense with respect to quantum mechanics (as popularly broadcast and received), other areas do not work so well. For instance, the logic of the bicycle-melding is somewhat flawed. It seems to insist that gravity is stronger than the strong nuclear force whereas, in fact, at very close range, the forces holding matter together are 10 to the power of 38 times stronger than gravity.

On the other hand, we also discussed the ways in which O’Brien’s fictional philosopher, De Selby’s, parody of Zeno might be a better representation of the debates around quantum mechanics. To briefly recap: in the novel, de Selby is a philosopher who believes patently absurd things. For instance, in a passage we studied on the evening, de Selby argues that motion is an illusion – a “fact” he deduces from observing a cinematograph. So far, the argument is exactly like Zeno’s. One can never reach one’s final destination, argued Zeno, because every time you travel half the distance to an endpoint, there are an infinite number of half-points still to travel; “inter-intermediate” points, as O’Brien calls them. Yet, in our discussion, we noted, there is a distinction between Zeno and de Selby. Zeno made his propositions while not really believing them; a sophist. De Selby seems to want to put them into practice. In many ways, this parallels the developments in quantum mechanics in the early twentieth century. The formulae seemed to work on paper, but some figures, such as Einstein, could not accept that this was a worldly reality: “God does not play dice”, he wrote, referring to the probabilistic elements of the Copenhagen interpretation.

The evening came to a close all too soon. The audience were engaged and many supplied contexts various and diverse in which we might read The Third Policeman. What I was left with, though, was a renewed sense of the novel’s humour. I had not read it for many years, yet in just the few pages that we studied, I felt drawn back in with a desire to reread to the text and its curious logics and languages. It may be, as with the narrator, that this is a text to which I will have to return, time and time and time again.

Science Week 2017: Resistance – film screening and panel discussion

Dr Clare Sansom, Senior Associate Lecturer in Biological Sciences, writes on the screening of Resistance: not all germs are created equal and panel discussion on antibiotic resistance, which took place as part of Science Week 2017

resistance_panel-disc-3Antibiotic resistance is one of the most crucial issues facing humanity in the early 21st century, with some commentators even suggesting that it poses as serious a threat to civilization as climate change. It was therefore timely that one of Birkbeck Department of Biological Sciences’ contributions to Science Week 2017, with its strapline ‘Microbes in the Real World’, should tackle the issue. This took the form of a screening of an award-winning feature film from 2014, Resistance (subtitle: Not all germs are created equal) followed by an extensive and lively panel discussion. The four panellists were scientists from the department whose research is geared to the development of antimicrobial drugs: Dr Sanjib Bhakta, a Reader in microbiology; Professor Nicholas Keep, Executive Dean of the School of Science and a structural biologist; and two promising students from Dr Bhakta’s lab: PhD student Arundhati Maitra and MRes student Alina Chrzastek.

Not surprisingly, given the timeliness of the issue and (it has to be admitted) the size of the venue – the tiny Birkbeck Cinema in Gordon Square – the session was over-subscribed. After a short introduction by Dr Bhakta, who used his own research field of tuberculosis to set out the ‘global threat’ of drug resistance, the packed audience were treated to 70 minutes of engaging and at times chilling documentary. The film, by US producers Ernie Park and Michael Graziano or, collectively, Uji Films, uses a combination of archive footage, animation, interviews and personal stories to explain how we have arrived at a point where antibiotics are failing and what we need to do to ‘save antibiotics in order to save ourselves’. Although the film was made in the US and focuses on US policies and case studies, the problem it describes is a global one and it would not have been difficult to find equivalent examples in the UK.

The producers weaved three case studies of patients who had suffered antibiotic-resistant infections engagingly through the footage. We were introduced to a teenage lad who had been exceptionally lucky to survive drug-resistant pneumonia with some disability; a fit, middle-aged man who picked up methicillin-resistant Staphylococcus aureus (MRSA) while surfing and is now seriously disabled; and, most harrowingly, a mother whose 18-month-old baby picked up a new strain of MRSA and died within 24 hours.

The film’s narrators explained that all antibiotics are ‘poisons that kill bacteria but not us’; if they don’t kill the bacteria they make them stronger. Using antibiotics in such a way as to promote this rapidly sets up a ‘Darwinian battleground’ in which weak bacteria are knocked out but strong ones survive. This can happen very quickly because bacteria grow and divide so fast. In the words of scientist and author Maryn McKenna, we had the only effective way of killing bacterial pathogens and squandered it. And we have done this in three main ways: by over-use in the environment, in agriculture and in medicine.

The first two of these are particularly prevalent in the US and some Asian countries and less of a problem in Europe, where regulation is stronger. In the US, antimicrobials are used in everyday household products, sprayed on everything from fruit trees to kitchen counters. And once farmers had realised that constant small doses of antibiotics made livestock grow faster and fatter, even in crowded, unsanitary conditions, they were determined to keep doing so even though it ‘makes as much sense as sprinkling antibiotics on your children’s cereal’. Most US-produced meat and poultry is now contaminated with resistant bacteria, and occasionally this is multi-drug resistant. A Danish hog farmer, Kaj Munck, explained the sensible approach taken in Denmark where antibiotic growth promoters in animal feed were banned in 1995 following an extensive public debate. The Danish pig industry is still profitable, producing 28 million a year: about the same as the state of Iowa.

The beginning of the antibiotic era in human medicine coincided with World War II, when it was seen as a ‘miracle drug’ for curing infected wounds. Over-use, however, started very soon: penicillin was given to overseas sex workers, not to protect them from infection but to prevent their US military clients from becoming infected. The danger of resistance was known as early as 1945, when Sir Alexander Fleming told the New York Times that “in such cases the thoughtless person playing with penicillin is morally responsible for the death of the man who finally succumbs to infection.” Doctors who prescribe antibiotics inappropriately are often not morally wrong, or even thoughtless, but over-anxious to avoid mistakes when the chance of an infection being bacterial is low but not vanishingly so. Readily available, rapid diagnostic tests would go a long way towards preventing this type pf misuse.

It would not matter as much if antibiotics became ineffective if there were other molecules ready to take their places. However, the current antibiotic pipeline is weak, with few drugs coming through. Pharma companies can spend at least a decade and a billion dollars on developing a single drug, so it makes more sense to work on drugs like statins that patients must take every day. We must begin to encourage and reward companies that bring forward antibiotic ‘drugs of last resort’ rather than best-sellers. In short, the film concluded, the problem of antibiotic misuse is a classic example of ‘the tragedy of the commons’; one individual’s over-use of antibiotics may be neutral or even beneficial, but if everyone does it there will be a huge problem. To win the arms race against bacteria we may need to redesign all the processes through which we discover, use and protect antibiotics, and to ‘use our wits to keep up with their genes’.

Bhakta introduced the panel discussion with a short explanation of the molecular mechanisms through which bacteria acquire resistance to antibiotics. Bacteria evolve quickly, and almost all have acquired some resistance either intrinsically, through mutations, or by acquiring resistance genes directly from other species. This is an inevitable process but we have some control over how quickly it occurs: good antibiotic stewardship is as important as innovative science for winning the ‘arms race’ described in the film.

Bhakta’s group at Birkbeck is interested in tackling the problem of resistance through discovering new compounds with novel modes of action and by aiming to ‘re-purpose’ some over-the-counter medicines that are already in use for other indications. Drugs in this category will have already been shown to be safe and are therefore quicker and cheaper to develop. Keep summarised the role of structural biology in antibiotic discovery as one of determining the structure of bacterial proteins that might be vulnerable to attack by drugs and identifying compounds that can bind to and inhibit them. We are now often able to see directly how these structures are changed by mutations that increase (or decrease) resistance.

Bhakta chaired the discussion that followed, which was extensive and wide-ranging, taking in politics and economics as well as science and medicine. Several questions touched on the role and responsibilities of the pharmaceutical industry, which is reluctant to invest in drugs that will only be used for short periods. More drug discovery than ever before is taking place in academic labs and small companies, often working together; Maitra, whose Birkbeck Anniversary PhD studentship is part-funded by Wellcome, highlighted the role of the Trust in promoting links with industry. Re-purposing drugs that have already been used clinically is much cheaper than developing a molecule from scratch. MRes students in Bhakta’s lab, including Chrzastek, are testing common anti-inflammatory drugs against Mycobacterium tuberculosis and have found some potentially useful activity although the mechanism of action is still to be explored.

Other questions focused on the need for strict antibiotic control measures. In many European countries, including the UK, antibiotics are only available on prescription and cannot be used as growth promoters in animal feed. This ‘best practice’ needs to be replicated worldwide, but it will be an uphill struggle. Bhakta told the audience that he often visits countries in south and east Asia where resistance is prevalent and has seen antibiotics available over the counter there. In countries without strong, publicly-funded healthcare systems there are often incentives for doctors to over-prescribe drugs including antibiotics. And even where this is not an issue, patients need to be educated to think of antibiotics as drugs of last resort rather than demanding them for every upper respiratory tract infection.

It was perhaps inevitable that someone would ask the ‘Brexit question’: in this case, is there a danger that we would reverse some of our ‘best practices’ when we are no longer bound by EU regulations? Encouragingly, Bhakta doubted that anyone would want to get rid of rules with such clear benefits. He felt that the now inevitable move of the European Medicines Agency, which regulates all medicines marketed in the European Economic Area, from London – and the confusion about how the UK drug market will be regulated – does present a danger, to our strong research base. And however the politics develops the international collaborations that UK-based doctors, scientists and entrepreneurs have built up over decades must be maintained.

Other Science Week 2017 events:

STEMing the flow – How can we keep women in STEM subjects?

This post was contributed by Lucy Tallentire, from Birkbeck’s School of Business, Economics and Informatics

stemming-the-flowMuch has been done in recent years to foster girls’ confidence in their abilities in Mathematics and Science, and go for a career in STEM (Science, Technology, Engineering and Mathematics). While 33% of the undergraduate course intake across these subjects in the UK is now female, the statistics on retention of female academics in STEM subjects are still far from indicating an even playing field. So does a career in STEM pose specific challenges for women? And what are the challenges when building a STEM career in the university sector?

These questions were among those discussed by guest speaker Professor Ursula Martin, CBE, who joined the Birkbeck TRIGGER team last week to discuss how female academics in STEM can navigate the challenges of a male-dominated sector. The event took the form of a conversation between Professor Martin, of the University of Oxford, and Dr Maitrei Kohli, who recently completed her PhD in the Departments of Computer Science & Information Systems and Psychological Sciences at Birkbeck.

Unconscious Biases

It was quickly agreed that, while a recent surge in opportunities for girls to engage with coding and science is certainly influential, a major responsibility to get more girls into STEM starts at home. Parents and early age role models are more likely to have a restrictive influence on aspiration if they impose social gender stereotypes on toys and activities – Lego and sport versus dolls and dancing. A key thing to consider is the parallels between these stereotypes and the STEM industries; there is an inherent need to first recognise unconscious biases in order to try to avoid them, and that needs to start at an early age.

Both Professor Ursula Martin and Dr Matrei Kohli had parents who encouraged them to develop their own interests. Dr Kohli, originally from India, went to a school which offered computing alongside other extra-curricular options such as music and dance. With parental support, she learned about computer science through basic exercises and play, and never saw herself as different to her male classmates. By contrast, Professor Martin had no access to science outside of her prescribed schooling:

“I went to a school where maths and physics were taught poorly. But before we took our GCSE equivalent exams, we got a new, much younger teacher who was an inspiration to many of us. There is certainly something to be said for motivating the next generation from a young age – you can’t re-educate girls of 13 to like a subject they have been put off from age three!”

The need for change

The low number of female professors of Computer Science in the UK begins with the low numbers of women studying the subject at university – less than 20%. However, while more and more girls are starting degrees in STEM subjects, women are still under-represented at professorial levels in all STEM disciplines, typically at 17%. This varies between disciplines and in computer science the current average is just 10%. This demonstrates a need for changes in universities so as to encourage more women to embark on and progress with a career in academia:

“There are a lot of different incentives for women to work in higher education, but more changes need to be made. For example, if a university board requires a female professorial representative, that woman is chosen from a much smaller pool of professors and adds an extra burden to their workload. This bias is also present at conferences and events, where women are not as well represented – but surely we should be encouraging careful work on a few very good papers rather than working frantically to present something new.”

After an insightful conversation, Professor Martin was asked what advice she would offer to the female researchers and PhD students in STEM, hoping to progress in their academic careers. Her answer: passion, hard work and confidence.

“There are challenges to every work-life balance and the important thing is to adjust, and make room for your passion and curiosity. There could not be a more interesting field – try to think of an area of work devoid of computers. Do not be put off by gloomy statistics; research in STEM is to be cherished as an interesting endeavour, and we must do more to promote it as an equal opportunity wherever and to whomever we can.”

Further information:

Science Week 2017: the source of human irrationality

Professor Nicholas Keep, Executive Dean of the School of Science, writes about Professor Mike Oaksford‘s Science Week 2017 talk on Tuesday 4 April
department-sliderProfessor Oaksford, the head of Psychological Sciences at Birkbeck, gave a talk on the source of Human Irrationality. There are proposed to be two systems for decision making.  System 1 is the older system shared with other animals and is fast and unconscious.  System 2 is slower and uses language and working memory to form a reasoned argument. It had been argued that irrational decisions arise from System 1 and System 2 is rational. However, Professor Oaksford argued the opposite. Studies of other animals such as starlings show that they are rational using System 1 and Professor Oaksford shows studies supporting the fast, unconscious response being rational in human. It is therefore, Mike argued, System 2 that leads to irrationality. It requires conversion of the unconscious processing into language and there is limited working memory to support system 2. Further, we do not (or cannot?) fully check all steps in our unconscious inference. The use of language can override our rational response and introduce errors of rationality.

What then is the advantage of language? It is that it allows us to be social and communicate our thoughts and plans with others thus accessing a wider range of experience and to store them in written form to recover them later. These social interactions should allow correction of our imperfect System 2 leading to better outcomes than System 1. I wold not be quite sure that this social correction is yet perfect judging by recent election results. There seems to be an ability to construct contradictory and mutually exclusive ‘rational’ views through social interaction.

Watch Professor Oaksford’s lecture on the source of human irrationality: